A character has daddy issues
A new mystery is introduced
Sawyer uses a nickname
Jack says "If we can't live together we’re gonna die alone" (drink two)
Someone comments on Hurley's weight
Kate does something stupid
Desmond says “Brotha”
A character named after a philosopher is introduced (drink two)
Literary reference (drink three)
Someone sees or mentions a polar bear
“Hollywood and Vines” motif (AKA the walking theme) plays (drink three)
Miles is snarky
A major character from another show plays a supporting or minor part
Clair say “My babay!”
A character drinks (If its MacCutcheon whiskey drink five)
Someone gets punched in the face (drink two if it’s Ben)
"You all everybody!"
Jin and Sun speak Korean on the island
Someone important dies (drink three)
Micheal say "My son," or 'My boy"
Nikki and Paulo are the worst
Lepidus doesn’t give a shit about this island mumbo jumbo
Ben says “I lied”
Hurley says "Dude"
Someone dead shows up in a vision, or imitated by the smoke monster, ect.
Kate makes out with somebody
Someone is in another character’s flashback (drink two)
Someone dead is in another characters flashback/flashsideways (drink three)
Locke says “Don’t tell me what I can’t do!” (drink two)
Confusion over Scott and Steve
Saiyid does some morally ambiguous shit
Sawyer says “Son of a bitch” (drink two)
Jacob is spoken about mysteriously or does some mysterious shit
A character says another character’s catchphrase (drink four)
Kate is a badass
Someone Sayid has slept with dies (drink five)
An episode ends in a cliffhanger (drink five)
And finally, whenever someone responds with "What?"